A woman has died in a multi-vehicle crash at Loftville on the Bruxner Highway this afternoon.

Emergency services were called to the Bruxner Highway at Loftville, about 7km south-west of Lismore, after a southbound Mazda 2 hatchback and a northbound truck and trailer collided head-on.

Police commenced CPR on the female driver of the car; however, she died at the scene. The woman is yet to be formally identified but is believed to be aged in her 50s.

The male truck driver was treated by NSW Ambulance paramedics for minor injuries, before being taken to Lismore Base Hospital for mandatory testing.

A third vehicle – a Mazda CX-7 also travelling south – sustained minor damage as a result of the crash but the driver was not injured.

Officers attached to Richmond Police District have established a crime scene and have commenced an investigation into the circumstances surrounding the crash.

The Bruxner Highway is closed in both directions, with diversions at Caniaba and Coraki roads. For your latest traffic updates, please visit www.livetraffic.com.

Inquiries continue.

Anyone with information about this incident – or who may have dashcam vision – is urged to contact Crime Stoppers: 1800 333 000 or https://nsw.crimestoppers.com.au. Information is treated in strict confidence. The public is reminded not to report information via NSW Police social media pages.